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Life Science

E 055.1
Laser Induced Forward Transfer
Complex structures can be printed using the innovative laser-printing technique LIFT (laser-induced forward transfer). This enables to deposit a bioactive film (cells, proteins, etc.) from a target with an absorber layer to be transferred to a substrate through targeted laser ablation (figure below). The transfer takes place via a laseractive absorber layer, which evaporates when irradiated with laser light. The resulting pressure wave transports the bioactive film across short distances onto a substrate.

Using a fast optical scanner it is possible to generate array patterns between 20?m and 300?m in size with up to 1000 spots/s. Any grid patterns can be processed using this technique. It was also demonstrated that vital cells can be specifically transferred.

Contact Person
Dipl.-Biol. Dominik Riester
Phone +49 241 8906-529
Fraunhofer Institute for Laser Technology ILT

E 034
Multiphoton Polymerisation
Multiphoton polymerization (MPP) is a high resolution stereolithographical process, which can be used to generate complex three-dimensional structures in the sub micrometer range. Usable materials cover a broad variety of photosensitive polymers, such as acrylic resins or biomolecules. Based on the physical principles of MPP, special processes and their technological implementation for applications in the field of tissue engineering will be realized.

Contact Person
Dipl.-Phys. Sascha Engelhardt
Phone +49 241 8906-605
Fraunhofer Institute for Laser Technology ILT

E 055.2
Temperature-controlled Coagulation
An increasingly acute problem in medical care is to deal with chronic wounds. The preferred treatment is placing a tight dressing on the entire area of the wound and to fix the dressing by putting staples into the skin. A new laser-based concept avoids these injuries by fixing the dressing by protein glue. The glue is applied in liquid form and can then be cross-linked with laser radiation. For the cross-linking to take place without damage to the tissue the temperature has to be in range between 55 - 70&grad;C for a few seconds. Because of the many variables in the wound situation the desired temperature cannot be set reliably just by inputting the laser parameters.

To circumvent these difficulties a new type of applicator with integrated temperature sensing is applied for bonding. When the sensor signal is fed into the feedback loop of the laser's power control that enables reliable coagulation of the glue in changing conditions. Thus the laser can cure the protein glue without overheating or damaging tissue.

Contact Person
Dr. Martin Wehner
Phone +49 241 8906-202
Fraunhofer Institute for Laser Technology ILT
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